rely on two or three crucial amino acid residues, constituting a catalytic diad or triad, respectively. In these enzymes, a nearby His side chain lowers the pKa of a catalytic Cys, enabling a ...

Discover the key differences between amino acids and proteins, and learn when it's most beneficial to consume each to ...

Synthetic biologists from Yale were able to re-write the genetic code of an organism—a novel genomically recoded organism ...

The structural hallmark of boronic acids is their boron atom, which exhibits the ability to form a tetrahedral coordination complex with various substrates. A key aspect of their chemistry is the ...

Proteins are the workhorses that keep our cells running, and there are many thousands of types of proteins in our cells, each performing a specialized function. Researchers have long known that the ...

Missense mutations are genetic alterations arising from the substitution of a single base pair (bp) in an amino acid (aa) sequence with a different base pair, resulting in the translation of a ...

Samples contain all five nucleobases of DNA and RNA, supporting theory that asteroids may have seeded Earth with life's ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

usually a carboxylic acid, -COOH, or one basic primary, secondary, or tertiary amino group, NC 1-3, [3,22,27,28,29] that determines the acid-base reactivity at clinical and pharmaceutical pH values.

Purpose: The chemical interactions that cause drug incompatibility in solutions, with emphasis on the acid-base and ionized ... of drug structures and pH and pKa values in relation to ionization ...

Several things can trigger acid reflux or a GERD episode, including some eating habits (like having dinner very late at night) or eating certain foods (like spicy, acidic, or fatty foods).