This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

Researchers at Karolinska Institutet, led by Dr. Helin Norberg and Dr. Erik Norberg, have identified a previously unknown ...

TFE3 overexpression attenuates α-Syn toxicity in a mouse model of Parkinson's disease. TFE3 overexpression rescues autophagy defects of dop ...

The amount of protein an individual needs depends on their age and sex. However, most adults on a 2,000-calorie diet require 50 grams (g) of protein daily. Protein is a part of every cell in the ...

Unlocking the potential of protein degradation in cancer research Donate Research and discoveries Study and careers Industry partnerships About us Support us Research and discoveries Find a researcher ...

Results: LPS (1 μg/mL) effectively inhibited cell viability, stimulated the expression of IκB-α and NF-κB, and simultaneously suppressed autophagy protein expression. The pro-inflammatory cytokines IL ...

The research team found how this process is controlled by a complex group of proteins that add a molecular signal to a cell membrane. This signal is a critical step in switching on the autophagy ...

It is observed that GSD can surpass the off-state degradation (OSD) stress mode. By separating different types of traps, we clarified the physical mechanism of GSD. Based on the understanding, a ...

It reinforced how mitochondria are deeply involved in balancing protein synthesis and degradation. It's something I'm eager to explore further." "The study suggests that MFN2's function in protein ...

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...