1 Esophageal Diseases Center ... reflux oesophagitis in humans began with T lymphocyte-predominant inflammation, and with basal cell and papillary hyperplasia developing before loss of surface cells.

Basal cell carcinomas, the most common form of skin cancer, occur in chronically sun-exposed areas such as the face. Locally advanced tumors in particular can be difficult to treat surgically.

although unlike cancer HGPIN retains a basal-cell layer. The recognition of HGPIN is clinically important because of the strong association between this disease and prostatic carcinoma.