Scientists map epigenetic changes during blood cell differentiation; Potential application for stem cell therapies Date: August 17, 2010 Source: Johns Hopkins Medical Institutions ...

Measuring the GATA1 and PU.1 proteins in single cells enabled the researchers to see that those proteins are not central players in blood cell differentiation. "For decades it was thought that these ...

Every second, an adult generates around five million new blood cells to replace aging or dying ones, ... Continuous map of early hematopoietic stem cell differentiation across human lifetime.

In blood stem cell differentiation, single-cell transcriptomics and imaging-based studies have demonstrated that key TFs are expressed in smooth, ...

More information: Luis Galan Palma et al, An unbiased genomewide screen uncovers 7 genes that drive hematopoietic stem cell fate from mouse embryonic stem cells, Blood Journal (2025). DOI: 10.1182 ...

More specifically, they captured “hundreds of clonal differentiation trajectories across tens of individuals and 230,358 single cells.” In young blood, thousands of different stem cells ...

Discovery of CXCL12’s role in red blood cell development could revolutionize artificial blood production and help address ...

A breakthrough in the understanding of how mammals create red blood cells could lead to opportunities for artificial blood to ...

It is generally believed that hematopoietic hierarchy in the fetal liver is established through the differentiation of fetal hematopoietic stem cells (HSCs). Using lineage tracing and HSC-depleted ...

This process, called differentiation, takes about two weeks and makes millions of blood cells, he says. These cells were then infused into mice that lacked an immune system and became functional ...

Many tumors have cancer stem cells that help them grow and evade treatments. Differentiation therapy forces these cells to mature, stopping growth with less toxicity than traditional treatments.