Adding bile acids as farnesoid X receptor agonists to the culture medium supported the growth and development of unique stem ...

Study identifies proximity-based mechanism behind LAG-3 inhibition and introduces novel bispecific antibody for autoimmune ...

Four days ahead of its July 7 PDUFA date, the U.S. FDA granted accelerated approval to Dizal (Jiangsu) Pharmaceutical Co. Ltd.’s sunvozertinib (DZD-9008), branded as Zegfrovy, for treating adults with ...

Drug discovery can be a long and complex process. Medicines for neurodegenerative diseases like Alzheimer's disease are among ...

This valuable manuscript investigates the localisation of nutrient receptors in bloodstream stage trypanosomes, with implications for both nutrient uptake and immune evasion. Results after direct ...

Kennedy researchers have uncovered key design parameters for bispecific T-cell engagers (TcEs)—a class of cancer immunotherapy drugs. The findings may help unlock the full potential of TcEs and ...

Abnormal regulation of Sonic hedgehog (Shh) signaling has been described in a variety of human cancers and developmental anomalies, which highlights the essential role of this signaling molecule in ...

The cell membrane receptors of juvenile hormone, CAD96CA and FGFR1, regulate the genomic effects of juvenile hormone by phosphorylating intracellular receptor.

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

However, the signal transduction mechanisms are not yet fully understood. To address this gap in knowledge, we aimed to identify the potential cell membrane receptor for CTRP9 by analyzing the ...

Septerna’s Native Complex Platform is designed to unlock GPCRs, which represent the largest and most diverse family of cell membrane receptors as hundreds of different GPCRs regulate physiological ...

Membrane receptors play important roles in the signal pathway to regulate cell functions, and therefore, they are usually the main drug targets. However, the study of cell membrane receptors in situ ...