One behavior which supports a cell’s ability to respond to both internal and externally-derived signaling is cortical excitability, wherein coupled positive and negative feedback loops generate waves ...

In conclusion, the dynamic and adjustable scaffold provided by the cortical actin network at the IS sustains key biophysical properties essential for antigen sensing and signal integration via the TCR ...

Here, we characterize a rapid and transient actin reset in response to increased intracellular calcium levels. Within seconds of calcium influx, the formin INF2 stimulates filament polymerization at ...

This defect correlated with a perturbation of the coupling between the clathrin coat and the actin cytoskeleton, which we confirmed in a cell-free assay of endocytosis. Our results indicate that a key ...