Main Congenital lactic acidosis refers to a group of inborn errors of metabolism characterized in the neonatal period by metabolic acidosis associated with an overwhelming accumulation of lactate.

Amid concerns over rising petroleum prices and resource depletion, organic compounds such as methanol are attracting attention as potential replacements. Though this bodes well in theory, the ...

Alexion measured whether ALXN1210 is able to normalise levels of a protein lactacte dehydrogenase (LDH), and reduce need for transfusion using Soliris as a benchmark over an eight week period.

Lactic acidosis, characterised by an imbalance between lactate production and clearance, is classified into type A and type B. Type A is associated with tissue hypoxia and shock, while type B occurs ...

Survival after extreme arterial acidosis is uncommon. A case of metformin induced lactic acidosis is described where the presenting pH was 6.38 exacerbated by hypothermia (29°C). Increased anion gap ...

Lactate accumulation in the solid tumor is highly relevant to the immunosuppressive tumor microenvironment (TME). Targeting lactate metabolism significantly enhances the efficacy of immunotherapy.

Aberrantly elevated lactate flux in tumors is increasingly recognized as a key driver of metabolic symbiosis, immunosuppression, and, ultimately, immunogenic chemotherapy resistance. Here, we propose ...

Group A used normal saline: persistent metabolic acidosis with hyperchloremia till the sample collected at 12 hours with mild deranged RFT in 16 children (88.8%). group B used Ringer’s lactate (LR): ...

BACKGROUND Non-invasive ventilation (NIV) reduces mortality and intubation rates in patients with chronic obstructive pulmonary disease (COPD) admitted to hospital with respiratory acidosis. This ...

Aim The aim of our investigation was to review the use of serum lactate dehydrogenase (LDH) testing in the Paediatric Emergency Department and to develop an appropriate algorithm for its use. Methods ...