Idaho investigators found a three-person mixture of DNA under the 21-year-old University of Idaho undergrad's fingernails after she and three friends were killed in her off-campus rental home in ...

Gene expression in bacteria is controlled by three main types of protein regulators: DNA-binding transcriptional regulators, two-component systems, and sigma (σ) factors of RNA polymerase. Since RNA ...

This holoenzyme is the main polymerase in E.coli DNA replication and is one of the family C polymerases. Polymerase III is made up of the clamp-loading complex, the beta sliding clamp processivity ...

The MPXV replicative holoenzyme contains catalytic polymerase F8 as well as a heterodimeric processivity factor consisting of A22 and uracil-DNA glycosylase E4.

Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus.

They determined the holoenzyme structure in complex with DNA using cryo-electron microscopy at the global resolution of ~2.8 Å. According to the findings, the holoenzyme possesses an architecture ...

The breast cancer specific tumour suppressor protein, BRCA1 (refs 1,2), activates transcription when linked with a DNA-binding domain3,4 and is a component of the RNA polymerase II (Pol II ...

Replication fork progression in Escherichia coli is catalyzed by a replisome composed of the DNA polymerase III holoenzyme (Pol III HE), which provides both the leading- and lagging-strand DNA ...

Introduction Replication of the mitochondrial genome depends on a set of nucleus-encoded proteins (Ciesielski et al., 2016b). The synthesis of mitochondrial (mt)DNA is catalyzed by the DNA polymerase ...

A review of the current understanding of RNA Pol III’s role in ageing, lifespan in different model organisms and the potential of Pol III as a therapeutic target to improve age-related health in ...

The control was performed in Figure 3, but in that experiment the Pol III*'s are not at a working fork with DnaB where things might be different. For example, two Pol III*'s might bind one fork ...