Cis-regulatory elements (CREs)—including promoters, enhancers, silencers, and insulators—are critical non-coding DNA ...

Our cells' identity is shaped by DNA tags called methylation. New tech, scDEEP-mC, maps these tags in single cells with ...

A new study shows AI can design synthetic DNA to precisely control gene expression in healthy mammalian cells. The model created custom enhancers from scratch, enabling selective gene activation or ...

A team led by University of Pittsburgh School of Public Health geneticists has shown, for the first time, that a gene “silencer” that resides in junk DNA is directly sparing people ...

Strikingly, enhancer regions can be thousands of DNA base pairs away from the genes they control. The 3D looping of DNA brings enhancers and the promoters of their target genes into contact.

CREs, including enhancers and promoters, are essential for controlling when and where genes are turned on or off. While their importance is well established, studying their activity at a large ...

Researchers have revealed a new mechanism underlying how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer ...

As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers ...

In some cases, enhancer-promoter interactions only happened when the gene was expressed, so the physical proximity between the two directly affected gene expression.