The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Using these assays, we have identified a nonpeptidomimetic small molecule chemotype that binds to SUMO1 but not SUMO2 or 3. NMR chemical shift perturbation studies have shown that the compounds of ...

Readthrough efficiency is often measured with dual reporter systems where the test stop codon and its surrounding nucleotides are flanked by an upstream reporter (often Renilla luciferase; R-luc) and ...

To estimate the readthrough efficiency of the AGO1 stop codon, these authors used a dual-luciferase reporter system in which AGO1-F-luc and R-luc were translated from separate mRNAs. AGO1-F-luc ...