Destruction of islet cells with streptozotocin in mice induced hyperglycemia, intravascular oxidant production, DNA strand breakage ... are expressed in pmol/mg protein; eNOS activity is expressed ...

AF2945); double stranded DNA (Cat. No. MAB030, MilliporeSigma, Burlington, MA, USA). Affinity-purified protein samples after incubation of ... Membranes were crosslinked using 1200 µJ UV light. Probes ...

These differences possibly reflect variation in the DNA binding specificities of packaging proteins, but are unlikely to alter ... the 40 kDa IVa2 produced two complexes in EMSA with the A1-A2 probe.

One-hybrid, EMSA, and RT-qPCR were used to demonstrate the function ... FLAG antibodies were employed for the immunoprecipitation of DNA-protein complexes. The raw data were subjected to quality ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or ...

Researchers from the Huntington's Disease Center, UCL Queen Square Institute of Neurology, and UK DRI at UCL have taken major ...

In a study published in Nature, researchers report the successful in vitro reconstitution of meiotic DNA double-strand breaks ...

In a study published in Nature Structural and Molecular Biology, scientists from the Department of Medical Biochemistry and ...

Both Tabrizi and Yang think that knocking down MSH3 could stave off HD pathology. Tabrizi noted that MSH3 also modifies other run-on repeats, including those causing fragile X syndrome, myotonic ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are cut ...

A new study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages ... A longstanding enigma in the Huntington's disease is how the ...