A new pathway in endocytosis has been identified in budding yeast, demonstrating the role of a specific compartment of the trans-Golgi network.

These pathways differ in the cargo they internalize, the signals needed for activation, the protein machinery involved in the endocytic process, and the fate of the internalized material (Figure 2).

The new endocytic mechanisms identified in this study are suggestive of similar transport pathways (compartments) in mammalian cells.

This study elucidated how exogenous RNAs enter fungi and identified the core components involved in fungal endocytic pathway.

Altogether, these results demonstrate that TGF-β receptors endocytose through clathrin-dependent and non-clathrin-dependent endocytic pathways, both of which are dynamin sensitive.

This novel endocytic recycling pathway employed a distinct set of molecular machinery to generate the recycling carriers and facilitate the unexpected kiss-and-run membrane fusion.

Eleven million Euros are provided under this program to the project "Endotrack" (Tracking the endocytic routes of polypeptide growth factor receptor complexes and their modulatory role on ...

These vesicles are then fused with early endosomes, which are the main sorting compartment of the endocytic pathway.

The researchers used three endocytic pathways as markers to sort out 29 non-small cell lung cancer (NSCLC) lines into two distinct clusters characterized by their endocytic dysfunction.

Taken up into the endocytic pathway, the fluorescent dyes co-localized with control bacteria known to traffic to lysosomes, yet surprisingly the dyes were unable to enter vacuoles containing C ...

This pathway is driven by ARF6, and the researchers demonstrated that this GTPase can regulate BACE1 trafficking as well. By transfecting cells with an ARF6 mutant locked in its GTP-bound state ...