University of Virginia scientists discover new cell organelle called "hemifusome" that helps manage cellular recycling.

This study elucidated how exogenous RNAs enter fungi and identified the core components involved in fungal endocytic pathway.

Scientists 'hack' cell entry to supercharge cancer drugs Rule-breaking drug design takes advantage of CD36-dependent pathway Date: April 17, 2025 Source: Duke University Summary: Scientists could ...

Preclinical data show intracellular uptake of a ligand-siRNA conjugate in vitro using megalin, an endogenous, endocytic recycling receptor on proximal tubular cells of the kidney Megalin-mediated ...

Preclinical data show intracellular uptake of a ligand-siRNA conjugate in vitro using megalin, an endogenous, endocytic recycling receptor on proximal tubular cells of the kidney Megalin-mediated ...

This novel endocytic recycling pathway employed a distinct set of molecular machinery to generate the recycling carriers and facilitate the unexpected kiss-and-run membrane fusion.

Methods Endocytic pathway proteins Rab5a and Rablla were used as vesicle markers to characterize the movement of integrins on the pathway.

In addition to the well-studied clathrin-mediated endocytic pathway, a variety of clathrin-independent pathways exist in eukaryotes. Shown here, many of the known CIE pathways share overlapping ...

A new pathway in endocytosis has been identified in budding yeast, demonstrating the role of a specific compartment of the trans-Golgi network.

The new endocytic mechanisms identified in this study are suggestive of similar transport pathways (compartments) in mammalian cells.

The new endocytic mechanisms identified in this study are suggestive of similar transport pathways (compartments) in mammalian cells.

Here, we review most used drugs and recently discovered small molecules able to block endocytosis and endocytic recycling pathways. We characterize such pharmacological inhibitors by emphasizing their ...