Germany, have developed a new method that makes it possible for the first time to image the three-dimensional shape of ...

The GABAA receptor binds to GABA (γ-aminobutyric acid), the major inhibitory, or calming, neurotransmitter in the adult brain. To function properly, the brain needs a balance of stimulating and ...

Many drugs - both legal and illegal - work on the GABAA receptor. Particularly well-known are the benzodiazepines, which are used for anesthesia during surgery and prescribed to treat epilepsy, ...

Researchers have just solved the first atomic structure of a brain receptor bound to a drug used to reverse anesthesia and to treat sedative overdoses.

CryoEM reveals three-dimensional atomic structure of the GABA A receptor. Binding pockets for GABA and flumazenil wedge between subunits. Results could allow better design of drugs to target the ...

This research has elucidated the structure of GABAA receptors, and the nineteen subunits they carry. It can also show how some drugs interact with this receptor. The samples used in this study were ...

The scaffolding molecules form a 5-nm thick density sheet to support and regulate GABAA receptors on the membrane. Together, they form an absorbing semi-ordered structure called "mesophasic assembly".

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor ...

The pentameric receptors formed a slim, cylindrical structure that passed through lipid nanodiscs. The extracellular domain of each subunit consisted of a single α-helix atop 10 β-strands, while the ...

The GABAA-receptor family has a crucial role in neural inhibition in the human brain. New structures of a GABAA receptor highlight the mechanisms of crosstalk between its binding sites.

These receptors are targeted by many drugs for a variety of conditions, and by studying receptors directly from human brains, this research provides new insights into their exact structure ...

Scientists have produced a map of a GABA receptor, revealing not just the receptor’s structure, but new details of how it moves from its inactive to active state.