The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution ...

Our bodies have to sense our environment, and receptors are one part of the sensory experience of the body. Receptors, such as those in taste buds... | Cell And Molecular Biology ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

A brand new biotech – Neurosterix – has been formed to take forward neuroscience programmes that originated at Switzerland’s Addex Therapeutics, including a drug for schizophrenia ...

Cerevel’s clinical pipeline also includes darigabat, an α2/3/5-selective GABAA receptor PAM currently under in a phase 2a proof-of-concept trial in epilepsy and panic disorder, due to read out ...