But scientists have now used human brain tissue donated by epilepsy patients to study the structure of GABAA receptors. These receptors are crucial molecules that help control the movement of ions in ...

It is currently developing three assets including AJ201, a first-in-class asset for spinal and bulbar muscular atrophy, BAER-101, an oral small molecule selective GABAA α2, α3 receptor positive ...

GABA primarily exerts its physiological functions through three receptor types: the ion channel receptors GABAA and GABAC ... exacerbates neuronal damage and disrupts the overall neural structure (103 ...

Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...

Brexanolone is a bioidentical to naturally occurring neuroactive steroid, allopregnanolone, a positive allosteric modulator of y-aminobutyric acid (GABAA) receptor. LPCN 1154 is expected to ...

Investigators at the Jacobs School of Medicine and Biomedical Sciences have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain, which could open up new ...

Ovid's most advanced pipeline programs include OV935 (soticlestat) in collaboration with Takeda and OV101 a δ-selective GABAA receptor agonist. Ovid's emerging pipeline programs include OV329 ...

Each cell of the human body contains two meters of DNA. The whole secret lies in the intricate three-dimensional arrangement that allows DNA strands to be efficiently organized and compacted within ...

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...