Researchers, led by Penn State biologists, have comprehensively predicted the location of potential non-B DNA structures in the newly available telomere-to-telomere genomes of the great apes.

In this issue, Nöllmann and colleagues report single-molecule analyses of DNA gyrase action on supercoiled DNA under different levels of strain. Surprisingly, they found that gyrase changes its ...

Using high-resolution cryo-electron microscopy researchers uncovered unprecedented detail of gyrase’s action on DNA.

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents ...

Kinase conformation reporters reveal how protein kinase activity conformations are influenced by regulatory protein interactions, patient mutations, and cellular drug binding, aiding in systematically ...

The team of researchers combined their expertise to study the interactions of DNA gyrase with DNA minicircles using recent technology advances in electron cryomicroscopy, an imaging technique that ...

In a study published in the journal Science, researchers at Baylor College of Medicine, Université de Strasbourg, Université Paris Cité and collaborating institutions reveal how DNA gyrase ...

First step to untangle DNA: Supercoiled DNA captures gyrase like a lasso ropes cattle Date: April 11, 2024 Source: Baylor College of Medicine Summary: Researchers reveal how DNA gyrase resolves ...

It’s long been known that DNA gyrase plays a role in untangling the overwinding, but the details were not clear. DNA minicircles and advanced imaging techniques reveal first step to untangle DNA “We ...

The NBTI’s quasi-atomistic binding-site surrogate modeling of S. aureus and E. coli DNA gyrase enzyme, respectively, was conducted by using the Quasar X 6.2 platform that allows construction and ...