This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights ...

The S. cerevisiae Pif1 helicase acts at G4 motifs 64, and members of the Pif1 DNA helicase family are particularly efficient in vitro unwinders of parallel intramolecular G4 substrates 59.

An international collaborative research team has discovered that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long ...

G-quadruplex (G4) is a unique nucleic acid secondary structure formed by guanine-rich DNA or RNA sequences through Hoogsteen hydrogen bonding among four guanines.

The team found that G-quadraplex DNA (G4-DNA) accumulates in neurons and dynamically controls the activation and repression of genes underlying long-term memory formation.

Their work, recently published in DNA Repair, reveals that DDX3X is actively recruited to sites of DNA damage, providing evidence for direct involvement in DNA repair beyond transcriptional regulation ...

Researchers have identified the mechanism used by the helicase ring to thread around and separate entwined DNA strands in the replication process.

The G4-DNA structure can therefore be involved in both the enhancement and impairment of transcription in active neurons, based on their activity, to enable different memory states.

DNA Nanopore Sequencing Adapted for Protein Sequence Comparisons Researchers link a stretch of DNA to a peptide of interest and measure current changes as the molecule is pulled by a helicase through ...

The researchers discovered that two of the helicase protein parts move along the strand while the other four tether it to the DNA, allowing the helicase to advance while staying securely on track.