Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.

Chemists have found a new way to determine 3D genome structures, ... known as Hi-C, ... so a single DNA sequence can give rise to many different possible conformations.

To explore the 3D morphology of the existing chromosomes, Aiden modified an in situ Hi-C protocol, dubbed PaleoHi-C. 2 This technique, adapted for ancient samples and combined with DNA sequencing, ...

Hi-C “glues” together sections that are near one another and tags the pairs. Alongside modern DNA sequencing, the technique produces a catalog of DNA fragments that interact in physical space. Like a ...

Using the genomes of modern elephants as a template, the researchers used Hi-C to create the first 3D map of the mammoth genome. This revealed that mammoths had 28 chromosomes, the same amount as ...

3D Genome Structure Guides Sperm ... can be physically close to the “enhancer” DNA switches that turn them on and off even if they are far apart in the DNA sequence. ... Namekawa and his students used ...

MIT chemists have now come up with a new way to determine those 3D genome structures, ... known as Hi-C, ... so a single DNA sequence can give rise to many different possible conformations.

Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.