Preservation of the coding potential of the genome and highly regulated gene expression over the life span of a human are two fundamental requirements of life. These processes require the action of ...

More information: Sina Shadfar et al, The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage, Aging Cell (2025).

Credit: Shutterstock LINE-1, a “jumping gene” making up 20% of the genome, invades DNA during cell division using protein-RNA clusters, offering insights into genome evolution and disease. Viruses are ...

Three Prime Repair Exonuclease 1 (TREX1) is the most abundant 3′ exonuclease in human cells, playing a pivotal and complex role in both autoimmune regulation and cancer immunity. Despite its ...

When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are difficult to repair. Now, scientists Irene Chiolo and Chiara Merigliano at ...

Prospective parents using IVF will soon be able to rank embryos using genetic and other information in the hopes of extending the longevity of their offspring, according to the 25-year-old ...

New research from USC Dornsife scientists reveals how cells fix dangerous DNA damage in hard-to-repair areas of the genome — a process that, when it goes wrong, can lead to cancer and other life ...