When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are difficult to repair. Now, scientists Irene Chiolo and Chiara Merigliano at ...

CryoEM structure of the RAD51 D-loop. Credit: eLife (2025). DOI: 10.7554/eLife.107114.1 Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells.

Breakthrough Research and Therapeutic Implications for Huntington’s Disease Mouse models have shown that targeting the DNA mismatch repair protein MSH3 can effectively halt or slow the expansion ...

The two proteins which interacted with the mutant FUS protein were PARP1, an enzyme promoting poly ADP-ribosylation (PARylation), a modification that can alter proteins in different ways, and histone ...

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes. Cell Reports, 2024; 43 (8): 114626 DOI: 10.1016/j.celrep.2024.114626 ...

Study reveals unique histone tag in oligodendrocyte progenitor cells, opening doors for advanced myelin repair therapies by CUNY Advanced Science Research Center Editors' notes ...

Click. Next, I would zoom in on the stretch of DNA with the typo and — click — run a piece of software that designs a CRISPR to repair the mutation. Click.

Error-prone DNA replication and repair may lead to mutations and cancer in individuals who inherit a mutant copy of the BRCA1 gene, according to a new study by Weill Cornell Medicine investigators ...

But the methods that look at the DNA select regions according to one histone modification at a time; they can’t look collectively at multiple modifications to see which ones are occurring together.

Introduction Chromatin organization and its dynamicity likely regulate the DNA-templated processes including DNA replication, DNA repair, and gene expression (Groth et al., 2007). The maintenance of ...