Trimethylation of histone H3 at lysine 4 (H3K4me3), is a type of histone modification that usually occurs during active gene transcription when the cell reads the gene to make a protein.

A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

Trimethylation of histone H3 at lysine 4 (H3K4me3), is a type of histone modification that usually occurs during active gene transcription when the cell reads the gene to make a protein. However ...

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation ...

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

In particular, bottom-up proteomics addresses the following quantification issues: (i) high amino acid sequence similarity between certain histone variants (e.g., 96% identity between human H3.1 and ...

These findings suggest that aberrant histone modifications in specific cellular subpopulations may drive disease progression, highlighting potential targets for diagnostic and therapeutic strategies.

Histone deacetylase 6 (HDAC6) is linked with various cellular functions, such as gene expression and protein degradation, as well as many diseases, including breast cancers and Alzheimer’s disease.