The original methods for targeting the IGF-I receptor in experimental animals were antisense strategies and dominant-negative mutants of the receptor. They are obsolete. Several antibodies to the ...

Although IR-B is a specific receptor for insulin, IR-A also binds IGF-2 and at lower affinity IGF-1, and may induce biologic effects in response to both IGFs. Second, overexpressed IR enhances the ...

Data show that PALSONIFY was well tolerated and IGF-1 levels remained stably controlled during long-term open label extensions of PATHFNDR-1 and PATH ...

The percentage of cells positive for IGF-1R ranged from 0 to 90 % ( 5 had 0%, 19 had > 10% and 17 had ≥ 50%), median 70%. Of the 17 patients with 50% or more cells positive for IGF-1R; 8 had extensive ...

Male and female mice in which the receptor for insulin had been deleted displayed normal timing of puberty and fertility, but male and female mice with the receptor for IGF-1 deleted showed ...

A growth hormone called insulin-like growth factor-1 (IGF-1) is likely to play a role in the development of breast cancer, according to two complementary studies published in Annals of Oncology.

Specifically, we've identified six VILPs within the Iridoviridae virus family. In this comprehensive project, our aim is to comprehend how VILPs interact with the insulin/IGF-1 system, influencing ...

Vitamin D and insulin-like growth factor-1 (IGF-1) are involved in a complex interplay that may have implications for growth hormone dosing, researchers found.

The type 1 insulin-like growth factor I (IGF-IR) receptor plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.

Data show that PALSONIFY was well tolerated and IGF-1 levels remained stably controlled during long-term open label ...