Figure 1. The insulin receptor substrate paradox. IGF-IR = Type 1 IGF receptor; IRS-1 = Insulin receptor substrate-1.

Importantly, the pro-oncogenic activities of IGF-1R are highly dependent on its proximal downstream effectors: insulin receptor substrate 1 (IRS1), and IRS2. 31, 32 IRS1 is upregulated in primary ...

Viridian Therapeutics Inc. (NASDAQ:VRDN) is one of the best low priced pharma stocks to buy now. Earlier on May 20, Viridian ...

THE IGF system comprises a phylo-genetically ancient family of peptides involved in growth, development, and metabolism, as well as in cellular processes such as proliferation, survival, cell ...

Crinetics shares PATHFNDR trial data showing oral Palsonify maintained hormone and symptom control in acromegaly patients ...

The Palsonify-treated subjects maintained control, with stable growth hormone levels, symptom scores, and pituitary tumour ...

Data show that PALSONIFY was well tolerated and IGF-1 levels remained stably controlled during long-term open label ...

Inhibition of Src and insulin/insulin-like growth factor-1 receptor (IR/IGF-1R) on tumors and bone turnover in prostate cancer (PCa) models in vivo compared with inhibition of either kinase alone.

"The results clearly showed that it is the insulin receptor -- not the IGF-1 receptor -- that is critical for the islet cell growth response to insulin resistance," said Dr. Kulkarni.

The precise genes involved in the control of ageing have been unclear, but several studies from invertebrates studies suggest that some of these life span genes encode components of the insulin or ...

The original methods for targeting the IGF-I receptor in experimental animals were antisense strategies and dominant-negative mutants of the receptor. They are obsolete. Several antibodies to the ...