Le Lézard5d
Pfizer's BRAFTOVI® Combination Regimen Significantly Improved Progression-Free Survival and Overall Survival in Phase 3 BREAKWATER Trial
Pfizer Inc. today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of BRAFTOVI® (encorafenib) in combination with cetuximab ...
Armed robbery in Revesby4d
Pfizer's BRAFTOVI Regimen Boosts Survival in Phase 3 Trial
Pfizer Inc. (NYSE: PFE) today announced positive topline results from the progression-free survival (PFS) analysis of the Phase 3 BREAKWATER study of ...
Nature5d
Immunological aspects of cancer chemotherapy
Imatinib mesylate, a protein tyrosine kinase inhibitor, can induce caspase-independent ... expressed by glioblastoma cells increased the sensitivity to inducers of cell death 87.
Frontiers5d
Cytochrome P450 Enzymes Involved in Metoprolol Metabolism and Use of Metoprolol as a CYP2D6 Phenotyping Probe Drug
Following the incubation in the absence (control) or presence of inhibitors, the reactions were terminated ... above show that CYP2D6 activity is not increased by the classical inducers of the CYP2B, ...
AI Alarabiya3d
Saudi Arabia’s Hevolution Foundation commits millions to transform healthspan research
Saudi Arabia’s billion-dollar-a-year healthspan initiative, the Hevolution Foundation, has unveiled a sweeping portfolio of ...
Nature5d
Apoptosis in animal models of virus-induced disease
Specifically, activation of caspase 3 leads to the breakdown of several cytoskeletal proteins, cleavage of poly (ADP-ribose) polymerase (PARP) and degradation of ICAD (inhibitor of caspase ...
Frontiers5d
Mechanistic causes of sign epistasis and its applications
It has been demonstrated that the occurrence or magnitude of sign epistasis can be altered by the environment, including the presence of inducers or inhibitors (Baier et al., 2023) and antibiotics ...
BioWorld1d
Mindrank describes new GSPT1 degradation inducers
New Drug Research & Development Co. Ltd. have identified molecular glue degraders comprising cereblon (CRBN) ligands acting as eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) ...
London Evening Standard6d
Arsenal vs Man City as it happened: Gunners humble champions in title statement
Arsenal delivered a statement of intent in the Premier League title race with a 5-1 hammering of champions Manchester City to close the gap at the top to six points on Sunday. Captain Martin ...
Digital Trends2d
Lenovo Legion Go S vs. Steam Deck OLED: here’s what we know so far
Lenovo’s Legion Go S was one of the worst-kept secrets for CES 2025, but now we don’t need to pretend anymore, as we’ve not only seen it in the flesh, but we’ve had enough time to give it ...
BioWorld2d
Merck Sharp & Dohme describes new Gag polyprotein (HIV-1)/protein Pol dimerization inducers
Merck Sharp & Dohme LLC has identified targeted activator of cell kill (TACK) compounds acting as Gag polyprotein (HIV-1)/protein Pol dimerization inducers reported to be useful for the treatment of ...
gut.bmj5d
Acute-on-chronic liver failure: an update
Correspondence to Dr Pere Ginès, Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona 08036, Spain; ...