Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

Protein Degradation Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell ...

In contrast to intracellular protein degraders, which require ubiquitin-proteosome cellular degradation, extracellular protein degraders can also harness endosomal-lysosomal protein degradation ...

New study identifies the determinants of targeted protein degradation for extracellular proteins, potentially leading to new therapeutics.

To unravel this ubiquitin code and understand protein degradation better, Leo Kiss and Brenda Schulman in collaboration with Leo James, head of the research group “Host-Pathogen Biology”, at the MRC ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These ...

Once PROTAC binds to its target protein and the ubiquitin ligase, the ligase will attach ubiquitin groups to the surface of the target protein, which tags it for degradation by the proteasome ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

“Protein degradation is based on intracellular processes, and it builds on the cell's natural system for recycling unneeded or defective proteins. This disposal process, which is called the ubiquitin ...

The study, published in Molecular Cell, revealed which Ubiquitin code can or cannot induce intracellular protein degradation. Proteins are the building blocks of life, maintaining cellular ...