Nature4d
Self-eating and self-killing: crosstalk between autophagy and apoptosis
LC3-II is used as a marker of autophagy because its lipidation and specific recruitment to autophagosomes provides a shift from diffuse to punctate staining of the protein and increases its ...
Frontiers4d
Sanqi Oral Solution Ameliorates Renal Ischemia/Reperfusion Injury via Reducing Apoptosis and Enhancing Autophagy: Involvement of ERK/mTOR Pathways
Representative western blot of PI3K III related autophagy protein SQSTM1/p62 and LC3, and the corresponding quantitative analyses. β-actin was used as loading control. Data were presented as means ± ...
Frontiers4d
Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway
Double-Labeled Adenovirus mRFP-GFP-LC3 Transfection and Autophagy Detection The L-02 hepatocytes were seeded and cultured in 12-well plates for 48 h, and then mRFP-GFP-LC3 adenovirus (GV540, Genechem, ...
Nature4d
The known unknowns of antigen processing and presentation
The autophagy machinery is thought to have an important role in the generation of peptide antigens for MHC class II molecules. The principal components of both MHC class I and class II antigen ...
jmg.bmj4d
Biallelic VPS35L pathogenic variants cause 3C/Ritscher-Schinzel-like syndrome through dysfunction of retriever complex
7 International Research Fellow of Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan (Standard)), Tokyo, Japan Correspondence to Dr Shinji Saitoh, Department ...