eLife14d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
The bottom LC3 blots represent a repeated immunoblotting experiment ... grouped according to the functions of the proteins in the autophagy process: autophagy induction signaling (A), membrane ...
eLife14d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
A similar issue is observed in the quantification of Endo-LC3. (6) In Figure S2A and Figure S2B, 17-month-old TRGL/Q175 mice show a decrease in p-p70S6K and the p-ULK1/ULK1 ratio, but no changes are ...
The EMBO Journal21d
Autophagy in Disease (2017)
While autophagy is relevant to many biological processes and often serves as a gatekeeper of homeostasis, when something goes wrong it can either lead to disease or be activated to fight against it.
PNAS27d
Ufmylation reconciles salt stress-induced unfolded protein responses via ER-phagy in Arabidopsis
Plants mobilize the endomembrane system for restoring homeostasis when stimulated by stresses. Though the function of ufmylation in ER stress and autophagy has been described in mammals, their ...
Medical Xpress27d
Powering brain health: How autophagy protects neurons by controlling their glucose consumption
Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...
Cancer Research27d
An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer
1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...