We need to identify other factors which -- over and above axonal loss ... Axonal loss in the multiple sclerosis spinal cord revisited. Brain Pathology, 2017; DOI: 10.1111/bpa.12516; ...

Nature Reviews Neurology - Axonal loss linked to MS disability. This new evidence builds on previous research indicating a primary role for axonal pathology in motor deterioration in animals.

When patients are diagnosed with MS and have their first neurological symptoms, axonal loss has already occurred. 6 Because brain atrophy, specifically gray matter atrophy, creates permanent ...

In recent years, the central roles of neuronal and axonal damage, as well as axon–glial and axon–myelin interactions, in the pathogenesis and progression of multiple sclerosis (MS) have become ...

Imaging studies at the NIH Clinical Center showed that chronic active lesions with a paramagnetic rim exerted ongoing tissue ...

Multiple sclerosis affects more than 2 million people worldwide ... Evangelou N, Ebers GC, Esiri MM. The contribution of demyelination to axonal loss in multiple sclerosis. Brain 2006;129:1507 ...

Pediatric-onset multiple sclerosis (POMS) is associated with higher likelihood of cognitive impairment and faster decline in information-processing efficiency, in adulthood, than adult-onset ...

Multiple sclerosis (MS) is an autoimmune disorder that results in incurable disabilities. Now, groundbreaking research conducted by Leipzig University and the Max Planck Institute has posed a new ...

Multiple sclerosis (MS), a chronic inflammatory disease of unknown etiology, involves an immunemediated attack of the central nervous system (CNS) that produces demyelination and axonal/ neuronal ...

For patients with acute optic neuritis, measuring early optic nerve lesion length may predict neuro-axonal loss and serve as a biomarker for chronic visual impairment in the future. CME.

Using a mouse model, researchers have found strong evidence that nicotinamide -- a form of vitamin B3 -- may protect against nerve damage in the chronic progressive phase of multiple sclerosis ...

About half of patients diagnosed with MS experience optic neuritis, which can cause mild to moderate permanent loss of vision, but rarely complete blindness. ST266 is a solution of molecules that ...