A new review highlights the pivotal role of LSD1 (lysine-specific demethylase 1) in regulating critical cellular processes ...

The critical role of EZH2, an essential epigenetic regulator, in cancer progression and treatment is underscored in this new review article published in Genes & Diseases.

Australians looking to take control of their health through genetic insights now have access to Life X DNA’s advanced home DNA testing kits, which provide an in-depth analysis of methylation-related ...

These insights hold significant promise for the future of horticulture and fruit breeding. By targeting DNA methylation pathways, researchers may be able to breed new apple varieties with more stable ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, United States Department of Biochemistry and Structural Biology, University of ...

DNA demethylation is the process by which a methyl group (-CH3) is removed from a DNA molecule. There are two primary mechanisms of DNA demethylation: active demethylation and passive demethylation.

This RNA-directed DNA methylation (RdDM) pathway preferentially targets euchromatic transposable elements. However, RdDM is thought to be recruited by methylation of histone H3 at lysine 9 (H3K9me), a ...

Metabolites from different metabolic pathways participate epigenetic regulation as cofactors. Dioxygenases such as HMTs and DNMTs use SAM as methyl group donor and ... SAM, S-adenosyl methionine; SAH, ...