Researchers from Nanjing Drum Tower Hospital reported findings from their evaluation of the role of NLR family CARD domain containing 5 (NLRC5) in post-stroke neuroinflammation. Immunofluorescence ...

Methods: We used superparamagnetic iron oxide to induce COHT in mice. Apoptosis of retinal ganglion cells (RGCs) and activation of microglia were evaluated using western blotting (WB) and ...

Focal ischemic brain injury of the sensorimotor cortex induced by photothrombosis caused more severe functional deficits in mice with IRF2BP2 ablated in macrophages/microglia ... subjected to cresyl ...

For example, active microglia can help clear the accumulated debris, such as unwanted proteins, cells and infections. The scientists in this latest study used mice that have the same brain changes ...

Lastly, the authors demonstrate that the male infertility caused by the studies mutation can be rescued by ICSI treatment at least in the mouse. This study furthers our understanding of male ...

We hypothesize that selenium deficiency increases oxidative stress and ROS-induced senescence in microglia, thereby contributing to neuroinflammation and cognitive decline. Methods: We fed aged ...

Background: Microglia-mediated inflammatory response directly affects ischemic stroke outcome. Autophagy is crucial in inflammatory response after cerebral ischemia. NLRC5 can be a positive or ...

Microglia act as the central nervous system’s primary defense mechanism. In older mice, they were working harder. (ART-ur/Shutterstock) “Aging is the most important risk factor for Alzheimer’s disease ...

After three months of enalapril feeding, behavioral experiments, serum tests, and tissue section staining were performed. Notably, enalapril had no significant effect on body weight in the mice, ...