The acute ventricular response to changes in cardiac workload depends on cardiac factors such as Ca ++ influx and activation of the myofilaments, fiber stretch prior to excitation, and factors ...

Evidence from cell culture and animal models indicates that HSP27 and αB-crystallin (cryAB) are dramatically regulated via phosphorylation in response to ischemic insults. The phosphorylation of these ...

The loss of cardiomyocytes in failing or cardiomyopathic hearts is gradual and not accompanied by inflammation or major histomorphologic deformity. Apoptosis, therefore, seems to be the most ...

The calmodulin antagonist W7 binds to troponin C in the presence of Ca2+ and inhibits striated muscle contraction. This study integrates multiple data into the structure of the regulatory domain of ...

On connaît bien le rôle défavorable de l’alcool sur le myocarde avec de très nombreux effets toxiques directs (apoptose, modifications des protéines au sein des cardiomyocytes, des myofilaments et du ...

This cycle of cell shortening and elongation is achieved by the movement of calcium in and around the cardiomyocyte. A protein called protein kinase GI? (PKGI-alpha) influences calcium movement and so ...