The Belgian-Dutch series is set in the titular state, a "heavily-surveilled" nation which is formed in a dystopian world.

Breast cancer is one of the most common cancers among women in the United States. Thanks to decades of fundamental research, it's also one of the most curable. The exception is a particularly ...

In sharp contrast, audience reviews of the film were extremely positive and laudatory, with one viewer writing: “One of the greatest war films ever put to screen. With an all star cast the complaints ...

Bladder cancers (BCs) that invade the muscle layer are classified as muscle-invasive bladder cancers (MIBCs). The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

Markus "Notch" Persson said on X that he "basically announced" Minecraft 2, but it might look a bit different than you expect.

Mechanistically, SOX2 inhibits Notch signaling by binding to NOTCH1 and NOTCH target gene promoters and/or enhancers and through direct interaction with RBPJ, suggesting that it interferes with the ...

Live imaging of the Notch co-activator Mastermind reveals that it promotes the formation of a dynamic transcription hub in Notch ON nuclei, conferring probabilistic transcription and providing a ...

Though NOTCH signaling is essential for heart development in mammals, it is unknown how the NOTCH1 gene regulates the differentiation and proliferation of human cardiac cells during development.

The involvement of the NOTCH gene family in HCC tumorigenesis has been previously discussed, yet insights on its effect on the immune microenvironment are still lacking. Methods: We systematically ...

Research identifies genetic risk factor for stroke Cysteine altering NOTCH3 gene variant, present in 1 in 300 people, identified as stroke risk factor in elderly patients Date: January 19, 2021 ...

A team of Geisinger researchers has identified a common genetic variant as a risk factor for stroke, especially in patients older than 65.

Given the high population frequency of NOTCH3 variants, the number of individuals who may be at higher risk of SVD and stroke as a result of a NOTCH3 variant is significant, the research team wrote.