Characterization of nuclear pore loss and dysfunction in nucleocytoplasmic compartmentalization in Alzheimer's disease neurons.

Treatment with an inhibitor of beta-amyloid production partially rescued the loss of nuclear pore proteins in young KI neurons, implicating beta-amyloid in Nuclear Pore dysfunction, a mechanism ...

Nuclear pore complex (NPC) biogenesis is a still enigmatic example of protein self-assembly. We now introduce several cross-reacting anti-Nup nanobodies for imaging intact nuclear pore complexes from ...

Nuclear pore complexes (NPCs) are cellular transport machineries embedded in the nuclear envelope that separates the cytosolic compartment from that of the nucleus in a typical human cell, providing ...

While Zaporizhzhia appeared secure on Friday, Russia’s seizure of the vast energy production site and potential targeting of another nuclear plant created risks of an accident.

Significance The nuclear pore complex (NPC) consisting of hundreds of proteins embeds into the nuclear envelope and functions as a selectively permeable barrier regulating the bidirectional ...

This showed the scientists that circulating T cells rely on the nuclear pore protein Nup210 to sense molecular signals vital for survival. "Peripheral T cell homeostasis is achieved by careful ...

La Jolla, Calif. - May 7, 2018 - Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus--they play an essential role in the survival ...

Nuclear pore complexes in the nuclear membrane not only control the transport of molecules into and out of the nucleus -- they play an essential role in the survival of T cells. A new study by ...

Two transmembrane nucleoporins and two nuclear lamina proteins were displaced from the nuclear pore, suggesting a structural disruption of this complex. Interestingly, expression of nucleoporins Nup85 ...