This ligand–receptor pair mediates endothelial and ... FN18 and antibodies against human CD4 (OKT4 from the ATCC hybridoma, Rockville, Maryland), human CD8 (DK25; DAKO, Carpinteria, California ...

For efficient mAb decoration, we have introduced a mAb binding Fc receptor (FcR) scaffold ... 314502, MHM-88), Pacific Blue-conjugated anti-human CD4 (cat.317424, OKT4), APC-conjugated anti-human CD8 ...

S3). Immunohistochemical analysis showed a dense lymphocytic infiltration of the lamina propria positive for T-cell receptor (TCR) α, CD3, CD4, and granzyme B but which did not express TRBC1 ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

(c) Glucocorticoid receptor (GR) protein immunoblot of whole thymus or purified CD4+ thymocytes. Antibodies to the glucocorticoid N terminus (top two panels) and DNA binding domain region (bottom ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

Tanaka and colleagues addressed the role of the C-C chemokine receptor 4 (CCR4) in early atherosclerotic plaque development using ApoE-deficient mice on a standard chow diet as a model. Because ...

Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of ...

Since HRES-1/Rab4 targets CD3ζ and CD4 for lysosomal degradation, we examined this process in NZB/W F1 mice. CD3ζ expression was reduced, while CD4 expression was unchanged in T cells of 4-week-old ...