Ectopic expression, gene knockdown and CRISPR/Cas9-mediated knockout studies of mutant p53 were performed to investigate p53-dependent drug effects. p53 signalling was examined using quantitative ...

RPE1 p53 KO, HCT116 p53 KO, RPE1 (H2B-RFP), MDA-MB-231 (H2B-mCherry), and Cal51 (Tubulin-mNeonGreen and H2B-mScarlet were endogenously tagged by CRISPR-Cas9) cells were originally obtained from Dr.

P53 and PI3K/Akt are important pathways by which MEG3 participates ... leading to cell apoptosis. MEG3 gene knockout significantly increased the viability of HTR-8/SVneo cells and reduced cell ...

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Bare-knuckle boxer Kaine Tomlinson Jr terrified fans inside with his brutal knockout at BKFC's KnuckleMania V. The KO of opponent Pat Sullivan inside Philadelphia’s Wells Fargo Center was so ...

Based on the manga by writer Aka Akasaka and artist Mengo Yokoyari, Oshi no Ko has a pretty wacky premise, involving a doctor and his patient who die and get reincarnated as the twin children of a ...

Jeremy Stephens def. Eddie Alvarez via third-round TKO (5:00) Ben Rothwell def. Mick Terrill via first-round KO (0:36) All former UFC heavyweight Ben Rothwell needed was 36 seconds to become the ...

In Tokyo, Japan, Naoya Inoue, the undisputed super bantamweight champion, successfully retained his titles on Friday morning with a fourth-round KO win over Ye Joon Kim. Inoue increased his ...

Patrick Sullivan is A-OK following a "KO of the Year" contender at KnuckleMania V. Known for his brawls as a hockey star, Sullivan stepped away from the ice for a future in bareknuckle boxing with ...