The structure–activity relationships and hit-to-lead optimization of dual Top1–TDP1 inhibitors in the indenoisoquinoline drug class were investigated. A series of nitrated 7-, 8-, 9-, and ...

Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in ...

Although there is some evidence that PDE5 inhibitors may have some beneficial effects in men with PE, well-designed clinical studies are still lacking.

The Recent PDE5 Inhibitors: Sildenafil, Tadalafil & Vardenafil in Male ED Since the early 1980s and 1990s, the physiology and pathophysiology of erectile function and dysfunction have been ...

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central physiological role in the regulation of cardiac function in both health and disease and thus represent one of ...

Complex glycans that are located at the surface of cells, deposited in the extracellular matrix and attached to soluble signalling molecules have a crucial role in the phenotypic expression of ...

Novel pyrazolopyridopyridazine derivatives have been prepared as potent and selective PDE5 inhibitors. Compound 6 has been identified as a more potent and selective PDE5 inhibitor than sildenafil (1).

Phosphodiesterase inhibitors and β-arrestin agonists are now considered as medication along with conventional drugs acting at G protein-coupled receptors. A molecular modelling technique is used here ...