Dr. Suneel Kamath discusses the ALASCCA study in colorectal cancer and highlighted the importance of next-generation ...

Quantitative real time polymerase chain reaction (qRT-PCR) and Western blotting assays were performed to measure the expressions of thrombospondin-1 (THBS1), TGF-β1, PI3K, AKT and phosphorylated AKT ...

The supernatant was then used for western blot analysis. GST-p30 and GST proteins were ... and the interaction between PARP9 and p30 may also inhibit the binding of PARP9 to PI3K and AKT3 activation.

The current PI3K 3C inhibitors in use in advanced breast cancer are alpelisib and inavolisib. Capivasertib is an AKT inhibitor, which is also used in PI3K 3C mutated breast cancer. So these are ...

Editor’s note: This is an automatically generated transcript. Please notify [email protected] if there are concerns regarding accuracy of the transcription. There are several clinical trials ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

On a recent winter afternoon in downtown Truckee, the sun dipped behind the mountains as a full moon rose above Donner Pass Road, the California city’s main thoroughfare. As the temperature ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

The best Western shirts also have fancy details like pearl snap buttons (that don’t come off as easily as regular buttons), and handy chest pockets that, while once used for cowboy essentials ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule-associated protein light chain 3 (LC3B), p-phosphatidylinositol 3-kinase (p-PI3K), phosphorylated AKT ...