Nature17d
PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation
Several studies have reported potentially anti-inflammatory effects of PPAR-γ ligands in monocytes and macrophages. Treatment of monocytes and macrophages with high concentrations of PPAR-γ ...
The Lancet12d
Antineoplastic effects of peroxisome proliferatoractivated receptor γ agonists
PPARs are ligand-activated transcription factors and have a ... including lipid biosynthesis and glucose metabolism. Endogenous ligands of PPARγ include long-chain polyunsaturated fatty acids, ...
Frontiers19d
Reporter cell lines for the characterization of the interactions between human nuclear receptors and endocrine disruptors
Though ERs are primary targets of EDCs, other members of the NR family, including AR, ERRγ, PPARs, TRs, RXRs, and PXR have been shown to correspond to secondary targets of EDCs. The weak structural ...
eLife11d
Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN signaling in ...
Frontiers19d
Targeting hepatic macrophages for non-alcoholic fatty liver disease therapy
Upon sensing their corresponding ligands and metabolites ... In NAFLD model mice, macrophage-specific PPAR-γ deficiency leads to enhanced metabolic activation of macrophages, which promote the ...
C&EN25d
Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform
We used the autofluorescent PPARγ ligand chiglitazar, omitted from the original ligand panel due to its autofluorescence, to probe the partitioning coefficients of such ligands. Chiglitazar contains a ...
BMJ19d
Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonists may become effective therapeutic targets. Objective To ...
The Lancet21d
Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia
dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...
BMJ16d
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
5 Pulmonary and Critical Care Unit and Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Massachusetts, USA 6 Division of ...