Several studies have reported potentially anti-inflammatory effects of PPAR-Ī³ ligands in monocytes and macrophages. Treatment of monocytes and macrophages with high concentrations of PPAR-Ī³ ...
Though ERs are primary targets of EDCs, other members of the NR family, including AR, ERRĪ³, PPARs, TRs, RXRs, and PXR have been shown to correspond to secondary targets of EDCs. The weak structural ...
Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonists may become effective therapeutic targets. Objective To ...
dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...
Modulation of ProteināProtein Interactions with Molecular Glues in a Synthetic Condensate Platform
We used the autofluorescent PPARĪ³ ligand chiglitazar, omitted from the original ligand panel due to its autofluorescence, to probe the partitioning coefficients of such ligands. Chiglitazar contains a ...
Laboratory of Biophysical Chemistry of Macromolecules, Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland; ...
A subset of these lipid mediators (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN ...
Figure 4 PPARs in macrophage function and polarization ... Interestingly, LTB4 and other fatty acid derived molecules are ligands for PPARĪ±, thus this feedback loop promotes their own catabolism and ...
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