PPARs exhibit a dualistic nature in cancer therapy, where their activation or inhibition can either suppress or promote tumor growth depending on the cancer type.

Peroxisome proliferator-activated receptors (PPARs) participate in the fatty acid oxidation, the homeostasis of lipid and glucose metabolism, the regulation of insulin sensitivity, and numerous ...

PPAR-α and PPAR-δ agonists modulate several complementary pathways. A key mechanism for both experimental therapies in treating PBC is the suppression of bile-acid synthesis, as evidenced by lower ...

Keisuke Yamamoto Tomohiro Tamura Rina Nakamura Shintaro Hosoe Masahiro Matsubara Keiko Nagata Hiroshi Kodaira Takeshi Uemori Yuichi Takahashi Michihiko Suzuki Jun-ichi Saito Kimihisa Ueno Satoshi ...

There is increasing evidence indicating that activation of peroxisome proliferator-activated receptor gamma (PPARγ) by its ligands can inhibit the growth of thyroid cancer, likely via multi-mechanisms ...

However, each can affect both positive and negative regulation of inflammatory and metabolic genes. PPARs are activated by both endogenous ligands and synthetic drugs. Endogenous agonists include ...

ABSTRACT: Background and Objectives: Peroxisome proliferator-activated receptor-g (PPAR-g) is a nuclear receptor whose activation regulates inflammation and fibrosis in various organs. We aimed to ...

Peroxisome proliferator-activated receptor (PPAR) agonists are used as adjunct therapy in the treatment of diabetes mellitus. Fibrates, including fenofibrate, gemfibrozil, benzafibrate, ciprofibrate, ...

The Peroxisome Proliferator–Activated Receptor (PPAR)- γ Antagonist 2-Chloro-5-Nitro-N-Phenylbenzamide (GW9662) Triggers Perilipin 2 Expression via PPAR δ and Induces Lipogenesis and Triglyceride ...

The nuclear receptor retinoid X receptor‐α (RXR‐α)–peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) heterodimer was recently reported to have a crucial function in mediating the deleterious ...

Troglitazone-suppressed stomach cancer via activation of PPAR-gamma, and stomach cancer was suppressed by apoptosis mediated by PPAR-gamma ligands. After we confirmed the appearance of PPAR-gamma ...