PPAR ligands exert their anti-inflammatory effects by inhibiting various transcription factors, such as NF-κB, by acting at many different levels, ...

Troglitazone-suppressed stomach cancer via activation of PPAR-gamma, and stomach cancer was suppressed by apoptosis mediated by PPAR-gamma ligands. After we confirmed the appearance of PPAR-gamma ...

PPARs exhibit a dualistic nature in cancer therapy, ... Additionally, the structural heterogeneity of PPAR ligands complicates the development of universally applicable pharmacophores.

However, PPARs manifest dual functions, ... Additionally, the structural heterogeneity of PPAR ligands complicates the development of universally applicable pharmacophores.

et al. Peroxisome proliferator-activated receptor γ ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines. Acta Pharmacol Sin 26 , 753–761 (2005). https://doi.org ...

PPAR-ligands are emerging as a new type of cancer therapy because they directly target errant cells and stop tumor growth, at least in animal models.

Via Megan McArdle, Derek Lowe blogs today about an entire field of pharmaceutical research revolving around PPAR ligands that pretty much went nowhere and cost drug companies a bundle: Allow me to ...

Peroxisome proliferator-activated receptor (PPAR) agonists are used as adjunct therapy in the treatment of diabetes mellitus. Fibrates, including fenofibrate, gemfibrozil, benzafibrate, ciprofibrate, ...

Peroxisome Proliferator-Activated Receptor Ligands Enhance Human B Cell Antibody Production and Differentiation. The Journal of Immunology , 2009; 183 (11): 6903 DOI: 10.4049/jimmunol.0900324 Cite ...

Background: Peroxisome proliferator-activated receptor-gamma (PPARγ) ligands have been identified as a potential source of therapy for human cancers. And, it is reported that PPAR-γ ligands could ...

The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose and lipid metabolism. They are activated by natural ligands, such as fatty acids, and are also target ...

PPARs exhibit a dualistic nature in cancer therapy, ... Additionally, the structural heterogeneity of PPAR ligands complicates the development of universally applicable pharmacophores.