Patients were randomized in a 1:1:1 fashion to sertraline [a selective serotonin reuptake inhibitor (SSRI)], mirtazapine (a noradrenergic and specific serotonergic antidepressant), or placebo.

In her new book, psychiatrist Joanna Moncrieff examines the popular belief that antidepressants "work." Among many other ...

The authors conclude that SSRI antidepressants are more effective than placebo only in patients with the most severe depression.

Sertraline, an antidepressant of the selective serotonin reuptake inhibitors and serotonin-specific reuptake inhibitor (SSRIs) class, displays a rather beneficial balance between efficacy and ...

A new Cochrane review confirms that antidepressants effectively reduce symptoms of generalized anxiety disorder (GAD) under trial conditions, although there is limited data on long-term usage.

Improvement in the CAPS-5 total score was significantly better at 10 weeks with the brexpiprazole-sertraline combination versus sertraline plus placebo ... and depression. "Results of this ...