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An oral drug called MA-5 can improve both heart and muscle problems in Barth syndrome. Testing the drug on cells from Barth ...
“We were able to show that EBV-infected B cells exhibit characteristics of ‘homing cells,’” Henri-Jacques Delecluse, MD, PhD, co-author of the study at the German Cancer Research Center ...
This patent, granted on October 8th, 2024, provides Lionheart Health, Inc., BioLeonhardt LTP, Valvublator, Inc., EyeCell, EarCell, KidneyCell, BladderCell, CerebraCell, CancerCell and other Leonhardt ...
CXCR2 and CXCR6 expression enhanced homing and anti-OS activity of B7-H3.CAR T cells. These findings support clinical evaluation of CXCR-modified CAR T cells to improve adoptive cell therapy for ...
However, T cells' "noses" often cannot pick up the scent of cancer cells, i.e., T cells do not express the receptors, which recognize the chemokines secreted by tumors.
Redirecting B7-H3.CAR T cells to Chemokines Expressed in Osteosarcoma Enhances Homing and Antitumor Activity in Preclinical Models. Clinical Cancer Research, 2024; DOI: 10.1158/1078-0432.CCR-23-3298 ...
They evaluated the homing kinetics (movement) and efficiency of the modified cells – testing their ability to find and infiltrate osteosarcoma.
Abstract. Acute myeloid leukemia (AML) remains with dismal outcomes, mostly attributed to the inability of therapies to eliminate leukemia stem cells (LSCs) leading to relapse. LSCs home to the bone ...
KAUST researchers have enhanced the functionality of CD34-negative hematopoietic stem cells, making them a promising option for treating blood-related diseases. By improving their bone marrow homing ...
However, Cldn11- deficient Sertoli cells increased SSC homing efficiency by >3-fold, suggesting that CLDN11 in Sertoli cells inhibits transmigration of SSCs through the BTB.
The authors revealed the critical role of SRSF1-mediated AS in precursor SSCs homing and survival, which may provide a framework to elucidate the molecular mechanisms of the posttranscriptional ...
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