Frontiers6d
ER stress, autophagy, and RNA viruses
Diagram of the UPR arms and their connection to ... ER-targeted proteins to reduce the load of ER client proteins during ER stress. The mammalian IRE1–TRAF2–JNK pathway, independent of XBP1 splicing, ...
GEN4d
Light Within the Black Hole of Concussion Therapeutics
A few companies are in clinicals with novel approaches to heal an initial brain injury or minimize secondary damage. Slow progress may be more related to investors’ misperceptions of the topic than ...
Frontiers6d
Transcriptomic and metabolomic analysis reveals the molecular mechanism of exogenous melatonin improves salt tolerance in eggplants
In this diagram, quadrants 2, 4, 6 ... The combined transcriptomic and metabolomic analysis revealed that melatonin activates the anti-stress metabolic pathways as well as the α-linolenic acid pathway ...
Rolling Out5d
The silent ways stress is wrecking your health
The constant activation of stress pathways in the brain can contribute to anxiety, depression, and mood instability. Individuals under persistent stress often experience feelings of hopelessness ...
Health on MSN17h
How Stress and Constipation Are Connected
Medically reviewed by Qin Rao, MD Managing stress is essential for feeling mentally and physically well. Stress can directly ...
Reuters4d
Fed releases 2025 bank stress test scenarios
WASHINGTON, Feb 5 (Reuters) - The Federal Reserve announced on Wednesday it would be testing big banks against heightened stress in commercial and residential real estate markets as part of the U ...
WebMD2d
Forever Chemicals Are Everywhere. Here’s How to Stress Less
Forever chemicals, PFAS (per- and poly-fluoroalkyl substances), endocrine disruptors, microplastics: These modern-day pollutants and man-made chemicals designed for durability are seemingly everywhere ...
Neural pathway in mice sheds light on how the brain regulates learned immune responses
The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have unveiled the existence of the so-called conditioned immune response (CIR), ...
The EMBO Journal4d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
eLife3d
Spatial confinement induces reciprocating migration of epidermal keratinocytes and forms triphasic epithelia
In this manuscript the authors established a novel three-dimensional culture system for stratified epithelia that allows epithelial cells to undergo epithelial-to-mesenchymal transition (EMT) and ...
verywellhealth4d
Stress Fracture Overview
A stress fracture is generally the result of overuse or repeated trauma to a bone. Also known as "fatigue fractures," stress fractures may occur when muscles become fatigued or overloaded and transfer ...