Tyler Jacks and colleagues used lox-stop-lox Trp53 knock-in alleles and a ubiquitously expressed Cre recombinase fused to a modified version of the oestrogen receptor (Cre ERT2).

A research team led by Professor Makoto Nakanishi of the Institute of Medical Science, the University of Tokyo, generated a p16-Cre ERT2 -tdTomato mouse model to characterize in vivo p16 high ...