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Small but mighty, viroids are disease-causing infectious strands of RNA that can self replicate. Unlike viruses, they don't possess any proteins of their own.
Viroids are like viruses, but smaller and simpler. They do not make any proteins and they don't have a protective coat. Despite this, they can still cause serious damage.
Research team published a comprehensive review on circRNA-disease association prediction, summarizing computational models into four categories and analyzing their strengths and limitations.
To date, viroids have only conclusively been found in plants. But some recent studies have indicated that similar agents infect other forms of life, too.
Viroids are tiny loops of RNA, a genetic cousin of DNA, and they've been found to infect primarily plants, such as potatoes. Viroids differ from larger, RNA-based viruses in several ways.
PATHOGENICITY MODEL:© National Academy of Sciences, USAViroid replication generates dsRNA intermediates, which are processed by Dicer into 21- to 25-nucleotide siRNAs. These siRNAs are then ...
CircRNA was synthesized with 5% m6A incorporation and the HRV-B3 IRES. mRNA was synthesized with CleanCap reagent, 100% N1Ψ incorporation, and a 120 nt poly(A) tail.
A team of researchers has developed a computational pipeline to identify and better understand viroids and viroid-like covalently closed circular RNAs (cccRNAs, also referred to as, simply ...
Norwegian biotech Targovax recently said it’s planning to rebrand as Circio, marking its shift from clinical stage immuno-oncology company to one focused on circular RNA (circRNA) therapeutics.. The ...
About 50 species of viroids have been identified in plants, with two currently known families, including Avsunviroidae and Pospiviroidae. Avsunviroidae use viroid-encoded autocatalytic hammerhead ...
Viroids are unique systems for the study of RNA structure, function and evolution. They are the minimal RNA replicons characterized so far ⎯their genome is ten-fold smaller than that the smallest ...
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