More than 400 million years ago, renin first appeared in organisms, 3 and renin is often seen as the first hormone discovered. Shortly before the 20th century, Tigerstedt and Bergman showed that ...

Previous clinical studies have reached a similar conclusion with regard to the predominance of Th1-type immune responses in graft arteriosclerosis by analyzing patient samples other than diseased ...

BACKGROUND: Apelin is an endogenous prepropeptide that regulates cardiac homeostasis and various physiological processes. Intravenous injection has been shown to improve cardiac contractility in ...

Persistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome that results from a failure of the pulmonary vasculature to transition to extrauterine life. Infants typically present ...

Methods and Results— Clinical data including operative mortality, IMH-related events, and long-term survival were retrospectively reviewed in 66 patients with type A IMH, who were admitted to our ...

Home Circulation Vol. 113, No. 12 Impact of Diabetes Mellitus on Regression of Electrocardiographic Left Ventricular Hypertrophy and the Prediction of Outcome During Antihypertensive Therapy Free ...

Relationship of BMPR2 Mutations to Vasoreactivity in Pulmonary Arterial Hypertension C. Gregory Elliott , Eric W. Glissmeyer , Gregory T. Havlena , John Carlquist , Jason T. McKinney , Stuart Rich , ...

In this issue of Circulation, Mukamal and colleagues report that frequent moderate consumption of alcohol is inversely associated with incident myocardial infarctions for both men and women. 1 This ...

Abstract Background— A better knowledge of patient x-ray dose and the associated radiation risk in pediatric interventional cardiology is warranted in view of the extensive use of x-rays and the ...

From the Michael E. DeBakey Veterans Affairs Medical Center Health Services Research and Development Center of Excellence, Houston, TX (S.S.V.); Section of Cardiovascular Research, Department of ...

Abstract Background— Mitochondrial DNA (mtDNA) copy number is decreased not only in mtDNA-mutation diseases but also in a wide variety of acquired degenerative and ischemic diseases. Mitochondrial ...

The main consideration in interpreting the findings is that the study used the phenotype of FH, defined as LDL-C ≥190 mg/dL, rather than a stricter definition (eg, one including a genetic diagnosis).