Former police chief and convicted killer and rapist Grant Hardin escaped from a prison in northern Arkansas on Sunday afternoon.Here's what we know right now:Escaped from a prison at Calico ...

SBI-810 is a β-arrestin-biased positive allosteric modulator (PAM) of the neurotensin receptor 1 (NTSR1), a receptor system distinct from the classical opioid pathway. In a series of rigorous ...

Discover SBI-810, a promising non-addictive painkiller that avoids common opioid side effects and addiction risks, offering hope for chronic pain sufferers.

More information: Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain, Cell (2025). DOI: 10.1016/j.cell.2025.04.038.

The arrestin-GPCR connection. Apr 15, 2019. Biophysicists decipher functionality of adrenaline-binding receptor. Jun 21, 2024. A step ahead in pharmaceutical research. Sep 6, 2018.

The scaffolding protein β-arrestin 2 regulates amyloid-β (Aβ) production via interactions with G protein-coupled receptors (GPCRs), and could represent a new therapeutic target for Alzheimer ...

The herbal substance kratom, derived from the leaves of a Southeast Asian tree, is used by nearly 2 million people in the United States annually. It can be easily purchased at gas stations and ...

Funding. Grants from the National Institutes of Health (R01-GM117923) and the Canadian Institutes of Health Research (PJT-162368 and PJT-173504) supported the research.

Glucagon receptor structures uncover new arrestin interaction mechanism. Chinese Academy of Sciences Headquarters. Journal Nature DOI 10.1038/s41586-023-06420-x ...

When TRV023 binds to AT1R, it activates the beta-arrestin signaling, but it blocks the G-protein signaling. Now, a team led by scientists at Duke University, in North Carolina, conducted a series of ...

image: Figure A-H: Higenamine induces β-arrestin 1/2-mediated transactivation of the EGFR/ERK1/2 pathway. view more Credit: ©Science China Press. The β 2-adrenergic receptor (β 2-AR) is a ...