Fibroblast growth factor 21 (FGF21) analogs significantly improve fibrosis and resolve metabolic dysfunction-associated steatohepatitis (MASH) without progression, showing promise for non ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

While Fibroblast Growth Factor 21 (FGF21) analogs have shown promise in clinical trials, their underlying molecular mechanisms remain unclear. A research team led by Prof. LI Yu at the Shanghai ...

Excessive consumption of sucrose, in the form of sugar-sweetened beverages, has been implicated in the pathogenesis of metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related ...

GSDMB can promote caspase-4 activity by directly binding to the CARD domain of caspase-4. (3) In the caspase-3-mediated inflammasome pathway, GSDME can also be cleaved by caspase-3 and lead to ...

KD with EX promoted WAT browning possibly via AMPK-SIRT1-PGC-1α, augmenting PRDM16, UCP1, FGF21, and FNDC5 expression ... in 5% (w/v) bovine serum albumin (BSA; Sigma Aldrich). After incubating the ...

The A/G ratio is a blood test that measures levels of albumin and globulin, the two main proteins in your blood. A high albumin-to-globulin (A/G) ratio may indicate kidney disease, an antibody ...