Frontiers20d
hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways
The anti-proliferative, anti-migratory, anti-invasive and pro-apoptotic effects of hERG activators were evaluated using the Cell Counting Kit-8, wound healing assay, transwell assay and cell apoptosis ...
SciTech Daily23d
Longevity Breakthrough: Scientists Restore “Youthful” Enzyme Activity To Combat Aging
Researchers at CCM Biosciences, Inc. have leveraged a novel biophysical mechanism of enzyme activation to discover and characterize groundbreaking enzyme activators for a previously untargetable ...
Medical Xpress27d
Powering brain health: How autophagy protects neurons by controlling their glucose consumption
Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...
Cancer Research27d
An Autophagy-Targeting Chimera Induces Degradation of Androgen Receptor Mutants and AR-v7 in Castration-Resistant Prostate Cancer
1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...